Tuesday, July 26, 2016

Alzheimer's and prions

I read another article about Alzheimer's and how sense of smell changes could help diagnose the disease. Very interesting.
Now it is time for one of Chuck's whacked out theories.

Recently there has been an increase in brain eating amoeba cases. Many of those cases were people who swum in waters during warm weather. The amoeba enters the nose migrates to the brain using olfactory nerves. It does this rather quickly since it is not a large separation relatively speaking.
Now what if there is another organism / agent that gains access to the brain in much the same way? A prion, a misshapen (misfolded ) protein. Prions have been proven to Mad Cow disease (BSE- bovine spongiform encephalopathy) and its human variant Creutzfeldt–Jakob disease (CJD).  Could a prion gain entry through the olfactory center propagate by misfolding of other alike proteins at a slow rate until it reached the brain? Upon reaching the brain could the prion be the cause the plaques and tangles found in the brain during postmortem studies of Alzheimer's patients? I know Alzheimer's has been identified as a protein misfolding disease so that part is not new. What if the source of entry is through the nose? Could it be a prion inhaled when cooking a certain meat or cooking it a certain way? Think about all the animal proteins we cook and all the different methods to do so? We know CJD is acquired from eating beef contaminated by the CJD prion. We also know that certain cattle feeding methods like supplementing the protein of beef cattle diet with beef meat byproducts (the parts of cattle they won't even use to make into hotdogs). Maybe there is another animal protein we use that has a prion that works slower either because of the way it is misfolded or because of its entry route. Maybe as we age changes allow this prion to reproduce faster.
I am not saying not to eat meat and become a vegetarian (I'm not giving up my carnivore ways) just maybe we should check this out to see if it is the cause, find the prion and where it originates. Find how it gains access to the brain and what makes some more susceptible.

This has been a way out there theory brought to you by the mind of Chuck.

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